Theodore Wensel Lab

Master
Heading

海角社区 the Lab

Content

The Wensel Lab research includes the following areas:

  • Visual transduction
  • G protein pathways and proteins that regulate them in the retina and the brain
  • RGS proteins: GAPs for heterotrimeric G proteins
  • Biomembranes
  • Ocular Proteomics
  • Cryo-electron microscopy and tomography
  • Gene repair in neurons
  • Phosphoinositide signaling
  • Super resolution fluorescence microscopy
  • Gene engineering in mice and frogs
  • TRP Channels
  • Primary cilia and retinal ciliopathies
Media Component
Dosey et al., 2018, Nature Structural and Molecular Biology
Ribbon diagram of side view, and space-filling model of view from outside cell of TRPV2 an important cation channel required for autoregulation of blood flow.
Heading

Structure of cation channel TRPV2 in open state

Media Component
TWFig3D2Rmut
Heading

Enhanced Serotonin Responses in Dopamine Receptor Mutants

Content

Serotonin responses of dopamine receptors engineered by evolution-guided mutagenesis.

Media Component
TWFig1RGS9loc
Heading

Localization of RGS9-2

Content

Localization of RGS9-2, a regulator of G-protein coupled receptors, in cultured striatal neurons.

Media Component
Wensel et al., Progress in Retinal and Eye Research, 2016.
3D structure of a daughter centriole from a mouse rod sensory cilium, determined by cryo-electron tomography and sub-tomogram averaging.
Heading

3D structure of daughter centriole by cryo-ET

Content

Cryo-electron tomography and sub-tomogram averaging was used to determine 3D structure of a daughter centriole from a mammalian rod sensory cilium.